Consider the scientific reality of H A injections. Used to replenish the synovial fluids , but doesn't do anything with the ligaments, tendons, or cartilage. (except as a side effect of having improved lubrication on THAT JOINT). It's real, and if synovial fluid is the problem, or a primary component of the problem, the results will be almost immediate... because of where and how it is administered.
At best, these type of injections are like squirting W D 40 on a squeaky hinge. It does nothing to the bent frame, the rust, or door's structural problem, but absolutely adds lubrication. It really masks a symptom of the rusty hinge or broken frame, for a time. Until the hinge starts squeaking again, or finally falls apart at some point in the future. The length of time will very, depending on the condition to begin with... the continued use, the care in future use, and any other repairs (or treatment) happening to it.
The reality is that H A injections alone can only help a limited amount of specific and direct joint issues. Generally only those related strictly to the synovial fluid (lubricating fluid). It is important to understand HOW the non-oral (ie. pure liquid) version of Hyaluronic Acid (H.A.) is used. When a doctor uses H A they INJECT.
Notice: most H A injections are done I A (intra-articular – directly in the afflicted joint), rather than I M (intramuscular - directly in the muscle) or I V (intravenous – directly in the blood stream). Positive results are less likely I V, and nearly impossible I M. It's been proven scientifically, tested both in the field and clinically over the last 20+ years. So, what about oral H A then?
CONSIDER: If it's known to be significantly less effective when directly injected into the body via I M and I V, one must rationally ask: "How can H A effectively get to the joint going through the digestive tract?"
Also, molecularly, H A is absolutely larger than Chondroitin Sulphate (C S), which science has proven only 8 to 10% of the C S can make it into the blood stream. So, the next question is: "How much oral H A do you think actually gets into the system?" These aren't new questions, with oral H A studies occurring the last 3 to 20 years by third parties have consistently shown only about 5% can be found to be absorbed 'in the body' with the majority of that mere 5% being found in the bone marrow and spinal column, and a fractional amount in the synovial fluids.
Over 90% of the oral H A passes through the system and is found in the poop in less than 24 hours. That makes some dang expensive manure!
Two of the most interesting studies were done by Wieder Int'l - one on rats, another on beagles (dogs) the results of both were consistent in what amount of radio tagged materials passed through the body, and where the small amount that was absorbed was found (the majority (over 90%) never made it to the joints).
Interestingly, all professionals that have actually paid attention to the science inject directly INTO THE JOINT to have a direct and real positive impact on the synovial fluid of that joint. They don't use Oral H A to treat anything!
Oral H A (Hyaluronic acid, which is also known as hyaluronate, also called hyaluronan, and is an anionic, nonsulfated glycosaminoglycan), may be an effective painkiller, for a time.
Another important scientific note: H A is also a component of the group A streptococcal extracellular capsule, and is believed to play a role in virulence. (Just wrap your head around that one).
Yet, in reality, injecting directly IN THE JOINT is the most challenging, dangerous, for a variety of reasons (especially for Equine Vets). But that is exactly where 99.9% of the H A injections occur by the professionals. Not directly into the blood stream which is safer, and not in the muscle which is so much faster and easier... and more effective systemically, with most 'medicines,' but that isn't how H A injections are given. Which should give all thinking people some pause, when the professionals won't administer it systemically... at a higher risk.
Then, when science shows the ingredients (the H A) doesn't survive, and isn't properly broke down or readily absorbed through the digestive tract, with the vast majority ending up in the poop (up wards of 90%)... the little bit that was 'taken up' was actually found in the spinal column and brain stem, one should wonder just exactly what it does in the body. It would stand to reason that it should be able to help all joint tissues in the body when injected directly into the blood stream... yet it doesn't. Therefore, it's not administered that way by the trained professionals.
Also, H A is made from rooster combs and bovine eyeballs... while natural to the mammals body, it is a non-native form (foreign to the body) not ‘designed’ for food stuff.
Excerpt from the review summary- "…dietary supplements containing H A are not equivalent due to the inherent properties of the three major types of H A commercially available as dietary supplement materials. Consumers and health care professionals need to be aware of the different types of H A and their very large differences in properties (even before ingestion). One source, hydrolyzed chicken sternal cartilage, is clearly unlike native H A it does not match the real biological properties of native H A and consequently should not be represented as H A to consumers on product labels..." yet supplement manufacturers regularly use this type of H A for oral application, many claiming it's a 'miracle.' At best, a smaller percentage might be actually used, but not by the actual joints, and upwards of 90% still passes through the body (unused).
Again, upon evaluation of WHERE the little bit that remained in the body was actually found (the spinal column and brain stem), it's highly likely, though unsubstantiated, that the effects tend to lean toward Cox-2 inhibitors (pain blockers and maskers - similar to what Vioxx did, before it was pulled from the human market). Oral H A is positively NOT 'building blocks' or nutrients otherwise considered 'healing promoters' (or agents) regardless.
Further, H A is also a major component of skin, where it is involved in tissue repair. When skin is exposed to exessive U V B rays, it becomes inflamed (sunburned) and the cells in the dermis stop producing as much hyaluronan, and increase the rate of its degradation. Hyaluronan degradation products then accumulare in the skin after U V exposure. Sounds good, right? Well, read on...
Hyaluronic acid is, thus, often used as a tumor marker for prostate and breast cancer. It may also be used to monitor the progression of the disease.
In some cancers, hyaluronic acid levels correlate well with malignancy and poor prognosis. H A is, thus, often used as a tumor marker for prostate and breast cancer. It may also be used to monitor the progression of the disease. It is important to note that the various types of molecules that interact with hyaluronan can contribute to many of the stages of cancer metastasis, i.e. further the spread of cancer. H A synthases (H A S) play roles in all of the stages of cancer metastasis. By producing anti-adhesive HA, HAS can allow tumor cells to release from the primary tumor mass, and if HA associates with receptors such as C D 44, the activation of Rho G T Pases can promote epithelial-mesenchymal transition (E M T) of the cancer cells.
During the processes of intravasation or extravasation, the interaction of H A S produced H A with receptors such as C D 44 or R H A M M promote the cell changes that allow for the cancer cells to infiltrate the vascular or lymphatic systems. While traveling in these systems, H A produced by H A S protects the cancer cell from physical damage. Finally, in the formation of a metastatic lesion, H A S produces H A to allow the cancer cell to interact with native cells at the secondary site and to produce a tumor for itself;
(Bharadwaj AG, Kovar JL, Loughman E, Elowsky C, Oakley GG, Simpson MA (2009). "Spontaneous metastasis of prostate cancer is promoted by excess hyaluronan synthesis and processing". Am. J. Pathol. 174 (3): 1027–36. PMC 2665762 Freely accessible. PMID 19218337. doi:10.2353/ajpath.2009.080501)
M.S.M. (Methyal Sulphanal Methane) is biologically active sulpher ...
and the particular variety MD's Choice uses is based on 26 animal patents, 26 human patents, by the original 'inventor' Dr. Bergstrom, and his company Bergstrom Nutrition, which exclusively manufactures Opti-M.S.M in the U.S. They have many long term studies, over the last 60+ years, on safety, effectiveness, use, lack of toxicity, and benefits to mammals (people and animals). It has been scientifically proven impossible for a mammal to overdose on,
What the body doesn't use, of their M.S.M. (which is the ONLY type of M.S.M. MD's Choice uses)... it passes through. There is no toxic build up, no known negative interaction with other medication or treatment. However, with that said, there are five other company's in the world which have attempted to copy the Opti M.S.M. ~ one in Alabama, one in South America, two in China, another in some more remote third world country.
Just like pie's aren't the same: Apple isn't Pumpkin, isn't Lemon Meringue, and it isn't just food or desert, verses Mud... there are significant differences. Far larger than what brand of gas you use in your vehicle (though the potential for contaminates and improved mileage because of quality absolutely exists in the nutritional ingredient world.
However, in nutrition, the differences are significant and important! And are far beyond just 'taste,' or personal choices, but hit actual safety, absorption, and effectiveness issues. and those differences are really more vital than just taste or smell, but what OTHER INGREDIENTS are used, and what 'contaminates' might be included in the M.S.M. (and other ingredients) that other companies make (and use), their purification process, and the care behind their manufacturing process.
At least 4 of the M.S.M. manufacturers are in countries 'we' wouldn't want to drink their water, so the purity and contamination of other substances should be of concern, and a valid question Especially since M.S.M. is a 'carrier' for other nutrients, and that was a serious concern the doctor's at MD's Choice considered when selecting the form and type they use, and where all the other ingredients in the products came from. Again, these 'other' forms of M.S.M., especially those created in other countries and shipped to the USA, should be a concern... and is the reason for the questions:
WHERE DOES the M.S.M. used in your products come from? Where were the RAW bulk ingredients originally manufactured?
M.S.M. occurs naturally in all meats, fish, poultry, eggs, milk, dark green vegatables, kelp, and algae among others. It is also naturally and normally found in foods containing sulfur, which are include grains, legumes, fresh unprocessed vegetables like garlic, onions, cabbage, broccoli and brussels sprouts.
As of 2017, any American supplement company claiming THEY 'manufacture' 'their' own M.S.M. is LYING! Because neither U.S. manufacturer of M.S.M. 'creates' their own line of mixed products (containing their MSM). They focus on bulk, raw M.S.M. only.
Chinese-made M.S.M. is generally not distilled but uses a crystallization process that traps contaminants (away from the active ingredients). Either way, it suffers from lower purity levels, a higher presence of unwanted chemicals left from the manufacturing process, and a higher water content, which leads to decomposition and increased contamination. They also frequently use lower quality raw materials to save costs. Chinese, and other third-world factories, undergo few of the health and safety inspections and safeguards. They lack the “Good Manufacturing Practice” (cGMP) certifications that American manufacturers are obliged to. So why chance using their 'biological carrier' (M.S.M.)?
What all was it tested for? What were the ingredients they are combining it with tested for? Because M.S.M will carry stuff into the body... into the blood stream, What ever it's attached to... so making sure there are no heavy metals or other containments is vital. Responsible manufacturers will also seek third-party testing for their finished products. These safeguards will ensure that each batch made is put through extensive analytics to ensure the absence of lead, arsenic, cadmium, aluminum, mercury, and microbes.
For quality M.S.M.
There are four additional tests that establish purity, quality, melting point (important to verify quality), water content (low water content is essential for stability), and shelf life. That information isn't public knowledge... but key to the reason MD's Choice uses the Opti-MSM.
People forget that herbs and spices CAN BE DANGEROUS... and really are "PLANT DERIVED DRUGS."
Yes, while some may be common or seem harmless to most people, most of the time, some are really deadly. Some are just dangerous under certain circumstances, over certain amounts, while others are fine topically... but deadly if ingested. Some are ok for culinary use, but not supplementation. All the while, others can be deadly to people with blood pressure issues, heart concerns, kidney or liver issues, and others dangerous only to breeding or pregnant mammals (yes, that includes people).
Balm of Gilead
Cohosh (see black, blue, and red)
False Unicorn Root
Lily of the Valley
Oregon Grape root
Queen of the Meadow
Vitex Agnus Castus
If you are shopping for (or using) a joint supplement, you absolutely want "Glucosamine Sulphate" in that product, preferably the 2KCl (potassium) form.,
The MD's Choice joint supplements are purposefully not liquid... because of the reality of the science! Contrary to the marketing hype: Glucosamine is NOT STABLE in liquid!
MD's Choice's products provide the other necessary basic building blocks to target the joint tissue, in high concentration, in forms the body can use. They do not mask the symptoms or kill the pain. However, just like the rest of the body, joints need to be fed every day, preferably 2 or 3 times a day, not just once a day, or every 4 - 6 weeks. Remember, the fastest, most effective, and economical way to address serious joint and connective tissue problems is to start a high quality oral supplement BEFORE the problem exists.
Preventive measures can really help a body be its very best, for the longest time. The MD's Choice joint formula actually helps improve the synovial fluids, but, more importantly, it also strengthens the ligaments and tendons (and all other connective tissue and soft tissues), and supplies the body (systemically) with basic building block nutrients required to help the body build healthy joint tissue, in forms the body can readily use. (Yes, that's a mouth full).
With the MD's Choice joint formula, the ingredients are generally absorbed into the blood stream within 30 to 45 minutes, and can be found in the actual joint tissue within 4 to 6 hours. That does not mean it's a 'quick fix' or relief will happen right away, it's nutrition - not a pain blocker or masker. It means that the body is getting the basic building blocks it needs, in the forms it can use, so it can start healing faster, easier, and better than it would have without those extra nutrients. It means the pain will decrease and go away over time, as the healing occurs. In other words, the MD's Choice joint formula does a whole lot more (and better) than oral H.A. by itself. And is better for the body than symptom blockers and pain killers. However, because of the potential for pain blocking in some bodies, which oral H.A. has shown with some, a few customers have reported a faster positive impact when they used oral H.A. in conjunction with MD's Choice's joint supplement.
MD's Choice has purposefully and knowingly avoided adding any pain killers and symptom blockers to their products, with the firm scientific belief that any such masking agents do NOT belong in a DAILY SUPPLEMENT INTENDED FOR DAILY PROLONGED USE.
Like any 'pain killer' - IF a person is going to use oral H.A.. it should be limited, controlled, and only used as needed... when needed... and daily use for more than 2 to 4 weeks at a time should be avoided.
MD's Choice has three primary joint supplements -
Remember, the MD’s Choice products are PURE NUTRITION!
The formulas on the key products have not changed since 1995, and It remains one of the most effective, most consistent, most bio-available (absorbable), and best 'joint formulas' on the market.
The prices have remained the same since 1998, with discounts and rewards available for people purchasing multiple containers at the same time. Including Current and Ex-Military, current and retired FOP Members, Fire fighters, k-12 educators, FFA, 4-H members, M.M.A. Competitors, NCAA and Olympic Athletes because we care… and know our product can help make a difference in bodies of all ages.
The Doctors that formulated these products have NEVER DRAWN A SALARY from MD's Choice (or VetSupplements.com)... that wasn't why they did it;They wanted consistent high quality products for themselves, their family & friends, patients and clients, but ultimately:
They wanted to help change the world... ONE BODY AT A TIME!
There are many doctors, veterinarians, nutritionists, chemists, and industry professionals we owe a special thanks to. But those listed above, and below, were extra important to the formulas and foundation of MD's Choice... and helped in some vital and important ways. Thanks to each and every one of them, and their continued contributions to help keep this project alive and moving forward!
Dr. LeAnn Blackford DVM, dAVCS
Dr. Martin DVM and CNS
Dr. Carla S. Sommardahl, D.V.M., PhD, Dipl. ACVIM
Dr. Cathy Johnson DVM
Dr. Sam Lyle DVM
Key People that helped MD's Choice:
Dr. Miller PhD in Nutrition
Dr. James Bailey a PhD in Nutrition
Dr. Sam Lyle, DVM
Dr. John Bennett, DVM
Dr. Mika Bentley DVM
Mr. Neil , CPA
Mr. Roy Metzger, Business Advisor
Key Distributors of our Products:
TN Farmer's Co-op
Valley Vet ~ National Catalog
Henry Schein Animal Health
KV Vet ~ National Catalog
Bulter Animal Health
Lextron Animal Health
Day to Day Operations:
Frank McAlister, COO
Terry Mercer, President
Ted McAlister (Part Time Help)
Bridgette Aldredge, Sales Rep
April DeBusk, Sales Rep
Russ Leamons, Sales Rep
Janis Beorkland, Sales Rep
Lori , Sales Rep
Walt Patrick, Sales Rep
All Research and Information ©1995 - 2017 MD's Choice, Inc. and respective holders. The legal mumbo jumbo: All information, graphics, and videos found on this site, and any sites directly linked from this site, are copyrighted and cannot be used commercially by any business, company, agency, or organization, without the express written permission of the respective holder. All rights reserved. Science, especially nutrition, is a vital part of life... living... and longevity. Nothing on this website, or any other, should ever be given more power or authority than your actual doctor: that has seen the body, ran the tests, poked, prodded, x-rayed or ultra-sounded when necessary, thoroughly examined, and genuinely evaluated the history of the patient. Part of the reason the FDA has regulations and requirements, such as “These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent disease.” is to help protect the consumer from false claims, 'magic cures,' 'miracle claims,' and dangerously avoidable contraindications (side-effects). We understand and agree! Drugs should have quality control regulations, safety requirements, and that includes all plant derived drugs (herbs) which have their place, but seldom ever in a 'daily supplement, intended for prolonged use.' Supplements should be tested for all the common contaminants, which MD's Choice has been doing since the very beginning. Nutrition is key, good nutrition important, but even the best nutrition doesn't replace the hands on experience of doctors able to evaluate the individual on a case-by-case basis. There are far too many ailments, types of diseases, genetic issues, contributing factors, and medical issues producing side-effects and symptoms for any responsible person - especially a doctor or healthcare related professional - to do more than generalize or suggest some elevated or minimized concern, without in-person testing and a real world exam. Our products are great, and have had the best Results Based Guarantee in the nutritional industry for over 20 years, which should tell you a lot about us. WE CARE... If you have a serious concern, or life threatening situation, PLEASE CONSULT YOUR DOCTOR, or a specialist that can see the body, do the tests, and evaluate the individual situation.